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Some physicians would stand by and see their patient die rather than use ascorbic acid because in their finite minds it exists only as a vitamin. F. R. Klenner, MD
Klenner successfully pioneered this therapy, here are his observations and recommendations.
Case 1: An eighteen-year-old female was treated just twenty minutes after a hornet bite. She was covered with hives and had shortness of breath and difficulty swallowing. In minutes after twelve grams of sodium ascorbate intravenously were pushed in with a 50 cc syringe her allergic symptoms were gone.
Dr. Klenner took ten grams of C dissolved in water orally and again in fifteen minutes to counteract the stings of fifteen yellow jackets. No symptoms.
Snakebite: He reported on a four-year-old girl bitten by a Highland Moccasin. She had severe pain in her leg and was vomiting within twenty minutes after the bite. Dr. Klenner gave four grams of C intravenously and within half an hour she had stopped crying and could now drink orangeade and began to laugh. "I'm all right now." She slept well all night, but because of a slight fever and tenderness, Dr. Klenner gave her another four grams intravenously and again that late afternoon. No antibiotics and no anti-serum were necessary.
Dr. Klenner had worked the schedule out on dogs and published it in hunting and fishing magazines. He has had many testimonials from satisfied doctors.
"All the venom that will be encountered exists as you see the patient. It is important to give sufficient sodium ascorbate to neutralize the bite. The more you give; the faster will be the cure. We now routinely give 10 to 15 grams sodium ascorbate depending on the weight of the victim. Then as much of the drug as can be tolerated by mouth is given, usually 5 grams, every four hours." Usually without the use of Vitamin C patients are stuck in the hospital requiring hot packs, antibiotics, anti-serum and nursing care. Many end up with much scarring."
From a later work:
The toxalbumin of the snake bite, like the copperhead or rattler; Formic acid plus a toxin with a protein cover, called proteotoxin by Arthus, 39 such as found in bees and wasps; Neurotoxin from the Black Widow, the Fiddle Spider and snakes like the Cobra and Coral; Production of histamine, especially in the more severe stings and bites. Wells 40 in 1925 called the poison of certain spiders and snakes zootoxins and of poisonous plants, phytotoxins. Ford 41 in 1911 reported three classes of toxins in plants and fungi:
Nerve poisons - muscarine; Those causing structural changes in the viscera with resulting fatty degeneration; Gastrointestinal irritants.
Ascorbic acid to the rescue.
It is a demonstrated principle that the production of histamine and other end products from deaminized cell proteins released by injury to cells are a cause of shock. The clinical value of ascorbic acid in combating shock is explained when we realize that the deaminizing enzymes from the damaged cells are inhibited by vitamin C. 42 It has been shown by Chambers and Pollock 43 that mechanical damage to a cell results in pH changes which reverse the cell enzymes from constructive to destructive activity. The pH changes spread to other cells. This destructive activity releases histamine a major shock producing substance. The presence of vitamin C inhibits this enzyme transition into the destructive phase. Clark and Rossiter 44 reported that conditions of shock and stress cause depletion of the ascorbic acid content of the plasma. As with the virus bodies, ascorbic acid also joins with the protein factor of these toxins effecting quick destruction. The answer to these emergencies is simple. Large amounts of ascorbic acid 350 mg to 700 mg per Kg. body weight given intravenously. In small patients, where veins are at a premium, ascorbic acid can easily be given intramuscularly in amounts up to two grams at one site. Several areas can be used with each dose given. Ice held to the gluteal muscles until red, almost eliminates the pain. We always reapply the ice for a few minutes after the injection. Ascorbic acid is also given, by mouth, as follow-up treatment. Every emergency room should be stocked with vitamin C ampoules of sufficient strength so that time will never be counted - as a factor in saving a life. The 4 gram, 20 c.c. ampoule and 10 gram 50 c.c. ampoule must be made available to the physician.
A case history - success due to promptness with a twelve gram injection.
As an example of the lethal effect of certain stings and bites, I briefly relate a case history. An adult male came to my office complaining of severe chest pain and the inability to take a deep breath. Stated that he had been "stung" or "bitten" 10 minutes earlier. Thinking that it was a Black Widow and not bothering to look for fang marks, due to the gravity of the situation, I gave one gram calcium gluconate intravenously. This gave no relief. He begged for help saying he was dying. He was becoming cyanotic. Twelve grams of vitamin C was quickly pulled into a 50 c.c. syringe and with a 20 gauge needle was given intravenously as fast as the plunger could be pushed. Even before the injection was completed, he exclaimed, “Thank God.” The poison had been neutralized that rapidly. He was sent home to locate the “culprit”. He soon returned with an object that looked like a mouse. It was 1½ inches long with long brown hair. There was a dark ridge down the entire back. It had seven pairs of propelling units and a tail much like a mouse. The following day I took "The Thing" to Duke University where it was identified as the Puss Caterpillar. This unusual caterpillar left 44 red raised marks on the back of its victim. Except for vitamin C this individual would have died from shock and asphyxiation.
Some concern answered regarding high dosage of ascorbic acid.
Merton Lamden, a bio-chemist, writing in the New England Journal of Medicine, Feb. 11, 1971, expresses grave doubts about the safety of large doses of ascorbic acid taken by mouth. He gives a report by Patterson 45 on the diabetogenic effect of dehydroascorbic acid on rats. Paterson in 1950 employed only the Ketone formula of ascorbic acid, dehydroascorbic acid, which he administered, undiluted, intravenously, in extraordinary amounts. His results were based on giving rats, weighing 100 grams to 120 grams, dehydroascorbic acid in doses from 20 to 50 mg. This transposed to a man weighing 70 kilograms would represent a dose of 3,500 grams - roughly 5,000 grams ascorbic acid. Obviously the work has no relationship with the ingestion of ascorbic acid by humans. I have taken from 10 to 20 grams of ascorbic acid daily since my last visit to this college—18 years ago. I do not have diabetes mellitus and if I might digress a moment, neither have I had a kidney stone.
See:
[1] Clinical Guide to the Use of Vitamin C
The Clinical Experiences of Frederick R. Klenner, M.D.,
abbreviated, sumarized and annotated by
Lendon H. Smith, M.D.
http://insights.rs79.vrx.net/sci/med/c/klenner-2/
[2] Observations On the Dose and Administration of Ascorbic Acid When Employed Beyond the Range of A Vitamin In Human Pathology
Frederick R. Klenner, M.D., F.C.C.P.
http://insights.rs79.vrx.net/sci/med/c/klenner-1/
[3] A Physician's Handbook on Orthomolecular Medicine
edited by Roger J. Williams, Dwight K. Kalita Page 57, at the bottom references Copperheads.
https://books.google.ca/books?id=X0_-BAAAQBAJ&pg=PA57&lpg=PA57&dq=copperhead+ascorbic+acid&source=bl&ots=pAozK96G_v&sig=SqyKSipleBmxH00i18mTcBTzgMM&hl=en&sa=X&ei=BqJnVZ2yEIW0yQTNhICYAQ&ved=0CD4Q6AEwBQ#v=onepage&q=copperhead%20ascorbic%20acid&f=false
[4] Klenner, F. R. "Case history: Cure of a 4 year old child bitten by a mature Hiland moccasin with vitamin C." Tri-State Med. J (1954).