The US Food and Nutrition Board lowered the RDA for selenium in the year 2000 from 70 mcg for men and 55 mcg/day for women to 55 mcg/day for both.



Nominal levels too low?

Niacin


"Niacin should be classified with the amino acids since it is made in the body from tryptophan and by definition vitamins cannot be made in the body; this was not known for a while and long usage has placed it in the vitamin camp. If it were thought of as an amino acid the large doses so effective in many diseases would be easier to understand" - A. Hoffer M.D., Ph.D., F.R.C.P.(C),
Negative and Positive Side Effects of Vitamin B3, 2003




Vitamin D


"The recent discovery that vitamin D regulates expression of the cathelicidin antimicrobial peptide gene has generated renewed interest in using vitamin D to fight infectious diseases." - Guo 2014



You can think of E as the oil version of C, it can be considered the primary lipid ("fat") antoixodant in the human antioxidant system. It can not be stressed enough that E, C and GSH (which has an absolute need for Selenium in its symthesis) work together. E regacrges C, C recharges E while Glutathione also recharges C.


by K. Gironda

... Genetics can make this more challenging. GAD1 helps convert glutamate into the calming neurotransmitter GABA. SLC1A2 and SLC1A3 help remove glutamate from the space between neurons to prevent overstimulation. GRIN genes influence NMDA receptor activity, one of the major glutamate receptors in the brain. COMT and MAOA influence dopamine, norepinephrine, epinephrine, and serotonin metabolism, which can amplify glutamate-driven nervous system activation. MTHFR, MTR, MTRR, and BHMT influence methylation, which supports neurotransmitter production and nervous system regulation. Mitochondrial genes such as SOD2, GPX, GST, NQO1, and other antioxidant pathways influence how well brain cells tolerate oxidative stress created by excessive glutamate signaling.

Diet can also increase the neurological burden. Monosodium glutamate (MSG), hydrolyzed proteins, yeast extracts, protein isolates, artificial flavor enhancers, aspartame in susceptible individuals, highly processed foods, and very large amounts of free glutamate may contribute to symptoms in sensitive people. Blood sugar instability, excessive caffeine, alcohol, poor sleep, dehydration, and chronic inflammation can further increase excitatory signaling. ...


N Acetyl Cysteine


A glutathione precursor, N-Acetyl-Cysteine(NAC) which is derived from the amino acid L-Cysteine.




b12 study 2025: Nominal levels too low?
https://www.news-medical.net/news/20250224/Normal-vitamin-B12-levels-may-not-prevent-brain-decline.aspx