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Marik explains his test and the data.
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Has this doctor found the cure for sepsis? Emergency care physician says vitamin C can prevent patients from going into organ failure
"Dr Paul Marik, chief of pulmonary and critical care at Eastern Virginia Medical School, believes he may have the cure for sepsis
Sepsis is a life-threatening infection that occurs when the body attacks its own organs and tissues. Patients with the infection are given an IV of vitamin C and steroids to reduce inflammation and the vitamin thiamine which helps with absorption. He says that since he tried the method in January 2016, he's treated 900 septic patients, with just two to three percent dying."
The authors (including Dr Marik) said that in 2015, 19 of 47 septic patients died, a mortality rate of about 40 percent.
But in 2016, just four of 47 septic patients died, all from underlying diseases rather than sepsis, a mortality rate of just eight percent.
Dr Marik said he's treated 900 patients with sepsis since he started in 2016, with just two to three percent dying.
'I thought we had an obligation to publish [the study] with the idea that this would be a stepping stone,' he said.
'We said it was a preliminary, observational study, and never claimed it was anything else.'
He adds the treatment, which costs just $40, is cheap, reduces a patient's stay at the hospital and responds better than the current standard of care
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Clinical trial testing vitamin and steroid combination in sepsis patients underway at Emory
"A new clinical trial at Emory University and 45 other sites around the U.S. will test a combination of vitamins and steroids in patients diagnosed with sepsis. Sepsis is caused by the body’s overwhelming and life-threatening response to infection that can lead to tissue damage, organ failure and death.
According to sepsis researchers, sepsis can account for 30 to 50 percent of all hospital deaths, making it the third leading cause of death in the U.S. Those numbers also make sepsis the most expensive reason for hospitalization, with annual expenditures exceeding $20 billion."
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How a mix of vitamins and steroids could cure sepsis: 6 things to know
"6. The approach to sepsis to be explored in the studies offers a more affordable, lifesaving treatment, the study authors said. "It's not going to be the equivalent of a new drug in cancer or hepatitis, which costs $50,000 to $100,000, and you have to make the decision if insurance doesn't cover it, whether or not to mortgage the house and give away your inheritance," Dr. Coopersmith told NPR. "This is something that's going to be very, very cheap and accessible throughout the world."
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Sepsis: Is There Now a Cure?
"This article has a lot of personal meaning because it reveals information that could have saved the lives of some of my family members…if only I had known about this sooner.
Here is what the Centers for Disease Control and Prevention reports on the impact of sepsis:1
About 250,000 Americans die from sepsis each year.
More than 1.5 million Americans get sepsis each year.
One in three patients who die in a hospital have sepsis"
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NOR in the US covered this in a number of articles expressing grave concern over a treatment that cured nearly every single patient.
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Could Vitamin C Be the Simple Solution for Sepsis?
"Could vitamin C be the simple solution for sepsis?
Just as the new international Surviving Sepsis guidelines come to publication this month, a Virginia physician becomes a small voice for practice change among his peers.
Dr. Paul Marik, chief of pulmonary and critical care at Eastern Virginia Medical School, believes he may have stumbled upon a possible aid in the survivability of sepsis. In his December 2016 study in the CHEST Journal, Marik and his colleagues describe their success with the use of intravenous vitamin C, hydrocortisone and thiamine in their patients with septic shock.
Inspired by current research findings using vitamin C in sepsis patients being performed by Alpha A. Fowler, M.D., at Virginia Commonweath University, Marik took the chance for hope in a severely, critically ill patient. After prescribing IV vitamin C and hydrocortisone as a last-ditch effort to save his patient's life, he returned the next morning to find her dramatically improved. In fact, she was transferred out of the critical care unit three days later.
Despite the skeptics, he soon began prescribing the new combination and was pleasantly surprised by the positive results. Of the 47 patients who were treated, only four did not survive, representing a mortality rate of 8.5 percent. The previous 47 patients not treated with the new regimen had 19 not survive with a hospital mortality rate of 40.4 percent.
Although these are small sample sizes of only one hospital population, it certainly has caught the attention of the medical community."
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IV Vitamin C, Hydrocortisone, & Thiamine for Sepsis
"Dr. Marik and colleagues found a hospital mortality rate of 8.5% in the treatment group, compared with a rate of 40.4% in the control group. Among patients treated with the vitamin C protocol, the propensity adjusted odds of mortality was 0.13. Sepsis-Related Organ Failure Assessment scores decreased for all patients in the treatment group, and none developed progressive organ failure. While patients treated with the vitamin C protocol were weaned off vasopressors an average of 18.3 hours after starting treatment, those in the control group had an average length of vasopressor use of 54.9 hours."
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Vitamin C cocktail for sepsis: randomized trials to test efficacy
"Jonathan Sevransky, MD of Emory University announced plans for a clinical trial enrolling between 500 and 2,000 patients at multiple centers over about 18 months, completing by the end of 2019. Patients with septic shock would get either the cocktail, or placebo. Mortality will be tested, as well as days free of vasopressors or a ventilator. The study will be funded by a private foundation.
Michael Donnino, MD of Harvard’s Beth Israel plans to enroll 200 patients at multiple centers, also testing the cocktail vs. placebo in patients with septic shock. Organ failure, mortality, and other outcomes will be compared. Major funding will come from the Open Philanthropy Project. The study should be completed in the autumn of 2019.
Researchers at Virginia Commonwealth University have concluded a randomized study enrolling 170 patients with sepsis-induced acute lung injury (ARDS), testing vitamin C vs. placebo on outcomes of organ failure, inflammatory biomarkers and ventilator support needs. Results have not been published at this writing."
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Vitamin Cocktail for Sepsis Getting Wider Test
"“There is in fact an enormous amount of basic science to support this,” he says. An Australian study found that if Marik’s mixture works, it could shave more than 40% off the long-term cost of treating the disease.
“The bottom line is it saves billions of dollars and millions of life-years, and at worst, if it doesn’t work, all it does is waste a little bit of money and nothing is lost,” he says."
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The Marik Protocol for Deadly Sepsis Is Already Saving Many Lives: The Roles of Vitamins C and B1 (Thiamine) - An Interview with Dr. Paul E. Marik, MD, FCCP, FCM, MBBCH
By Richard A. Passwater, Ph.D. - October 16, 2018
Marik: Dr. William Osler is quoted as saying, “Except for a few occasions, patients appear to die from the body’s response to infection rather than from the infection itself.” Sepsis results from the host’s response to infection being dysfunctional and going out of control resulting in damage to a variety of organs and ultimately resulting in organ failure and death.
Passwater: What causes sepsis? Why does an infection turn into deadly sepsis?
Marik: The most common causes of sepsis are pneumonia, urinary tract infection and intra-abdominal infection. An infection turns into sepsis because of a dysfunctional host immune system; this likely related to bacterial and host risk factors.
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