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IV Ascorbate reduces ER Sepsis Deaths from 50% to 1 in 150, a 7500% increase in survival.
IV Ascorbate reduces ER Sepsis Deaths from 50% to 1 in 150, a 7500% increase in survival.

"Klenner's paper (Klenner FR. The treatment of poliomyelitis and other virus diseases with vitamin C. J. South. Med. and Surg., 111:210-214, 1949.) on curing 60 cases of polio in the epidemic of 1948 should have changed the way infectious diseases were treated but it did not." - Robert Cathcart "

Despite being known to science for decades Vitamin C was finally given a fair trial at one Hospital in Norfolk Virgina. Early advocates such as Dr. Peter Levy suggest "the genie is out of the bottle", and once hospitals start experiencing the same increase in survival shown in Norfolk it should spread. Who wants to be the last US hospital to lose half their ER Sepsis patients?

New Zealand has already done this, it was covered by by the ABC television program "20/20".

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Applications

Oxidatative stress and the Ebola virus.
Enhanced Vaccine Disease.
Flu and upper respiratory infections

Sepsis is rather an archaic term, as is "blood poisoning" although the latter is perhaps more accurate. Here are some examples of where it may occur.



news

Clippings from the lay press.

Video with Paul Marick
Has this doctor found the cure for sepsis? Emergency care physician says vitamin C can prevent patients from going into organ failure
Clinical trial testing vitamin and steroid combination in sepsis patients underway at Emory
How a mix of vitamins and steroids could cure sepsis: 6 things to know
Sepsis: Is There Now a Cure?
National Public Radio
Could Vitamin C Be the Simple Solution for Sepsis?
IV Vitamin C, Hydrocortisone, & Thiamine for Sepsis
Vitamin C cocktail for sepsis: randomized trials to test efficacy
7500% improvement in survival rates of sepsis.
The Marik Protocol for Deadly Sepsis Is Already Saving Many Lives: The Roles of Vitamins C and B1 (Thiamine) - An Interview with Dr. Paul E. Marik, MD, FCCP, FCM, MBBCH

This made the US national media.


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Next Generation/Future directions

Selenium improves sepsis recovery by 10%
Hydrocortisone and Ascorbic Acid Synergistically Prevent and Repair Lipopolysaccharide-Induced Pulmonary Endothelial Barrier Dysfunction.
Tocopherol improves Neonatal sepsis recovery by 10%
Ascorbate-dependent vasopressor synthesis: a rationale for vitamin C administration in severe sepsis and septic shock?
Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes.
Oxidative stress causes reversible changes in mitochondrial permeability and structure
Ascorbate and Thiamine improve sepsis recovery by 7500%

Marik et al in the spring of 2017 at a hospital in Norfolk Virginia lowered the death rate of ER Sepsis from 50/50 to 1 in 150* with the simple addition of L-Ascorbate, and Thiamine to the usual cortisone IV. However there is room for improvement as L-Ascorbate is merely one of a handful of substances that do the heavy listing here; that is it is merely one part of the antioxidant system and it is reasonable to suspect an improvement by supplying all five the substances this biochemical pathway requires and not just the most important one as they work together as synergistic co-factors. Many doctors are not aware of the specifics of this chemistry.

The 1 in 150 who died had Alzheimer's and was hit by car, he survived sepsis.


tech

Mentions in medical journals

Sepsis is implicated in 20 per cent of deaths worldwide and is twice as prevalent as previously believed. In 2017, 11 million people worldwide died in connection with sepsis.
Vitamin C & Thiamine in Sepsis
Vitamin C: The next step in sepsis management?
Ascorbic acid, corticosteroids, and thiamine in sepsis: a review of the biologic rationale and the present state of clinical evaluation
Evidence is stronger than you think: a meta-analysis of vitamin C use in patients with sepsis
Vitamin C, Thiamine, and Hydrocortisone for Sepsis Patients
Vitamin C for the treatment of sepsis: The scientific rationale
Vitamin C cocktail for sepsis: randomized trials to test efficacy
Could vitamin C save lives in sepsis? These hospitals aren’t waiting for proof.
Metabolic sepsis resuscitation: the evidence behind Vitamin C

Diseases per se may not kill you directly. Sepsis is an unfortunate side effect of nearly every disease. It's how you die from flu for example, or Ebola. "Sepsis" is an ancient word, today we say "Oxidative Stress" where the body's antioxidants are destroyed faster than it can regenerate or ingest them.

Once an antioxidant molecule in the body (there are many types) has been used up, or oxidized it is regenerated but these chemical reactions require: ascorbate to recycle ascorbate and selenium to recycle glutathione. Without these two chances of surviving sepsis are grossly unfavorable.

The key point here is if you survive sepsis your chances are pretty good. If noting else you're getting better now not worse. Note also these can be given before sepsis starts and will highly reduce the chance of the disease getting that far.

People that tend not to get the flu take this anyway. They're not the ones that go into septic shock and die.

" Vitamin C is a key cellular antioxidant which counteracts these ROS. In addition, vitamin C recycles other antioxidants including α-tocopherol (vitamin E) and tetrahydrobiopterin (BH4). BH4 plays a critical role in the function of endothelial nitric oxide synthase (eNOS). Vitamin C deficiency results in the incomplete regeneration of BH4 resulting in the uncoupling of eNOS and the generation of superoxide and peroxynitrite [11]. Vitamin C inhibits activation of nuclear factor kappa-B (NF-κB), a major nuclear transcription factor involved in release of numerous proinflammatory mediators [12]. Vitamin C is an essential cofactor for the activity of monooxygenase and dioxygenase enzymes, including those enzymes required for the synthesis of catecholamines and vasopressin [13]. In addition, vitamin C binds adrenergic receptors increasing catecholamine sensitivity (acts like a vasopressor agent)."